I recently acquired an Intel based server and plugged it into my AMD-based Proxmox cluster. I ran into an issue transferring from AMD to Intel boxes (the other direction worked fine.) After a few moments, every VM that moved from AMD to Intel would kernel panic.

Fortunately I found here that the fix is to add a few custom CPU flags to your VMs. Once I did this they could move back and forth freely (assuming they had the kvm64 CPU assigned to them – host obviously won’t work.)

qm set *VMID* --args "-cpu 'kvm64,+ssse3,+sse4.1,+sse4.2,+x2apic'"